Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies. Novel therapeutics that can improve contractility...

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Veröffentlicht in:JACC Basic Transl Sci
Hauptverfasser: Sharp, Thomas E., Kubo, Hajime, Berretta, Remus M., Starosta, Timothy, Wallner, Markus, Schena, Giana J., Hobby, Alexander R., Yu, Daohai, Trappanese, Danielle M., George, Jon C., Molkentin, Jeffery D., Houser, Steven R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
Schlagworte:
PRECLINICAL RESEARCH
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058945/
https://ncbi.nlm.nih.gov/pubmed/30062182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2017.06.007
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