Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies. Novel therapeutics that can improve contractility...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Sharp, Thomas E., Kubo, Hajime, Berretta, Remus M., Starosta, Timothy, Wallner, Markus, Schena, Giana J., Hobby, Alexander R., Yu, Daohai, Trappanese, Danielle M., George, Jon C., Molkentin, Jeffery D., Houser, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
PRECLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058945/
https://ncbi.nlm.nih.gov/pubmed/30062182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2017.06.007
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