A Caveolae Targeted L-type Ca(2+) Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Cardiac Contractility

RATIONALE: The source of Ca(2+) to activate pathological cardiac hypertrophy is not clearly defined. Ca(2+) influx through the L-type Ca(2+) channels (LTCCs) determines “contractile” Ca(2+), which is not thought to be the source of “hypertrophic” Ca(2+). However, some LTCCs are housed in caveolin-3...

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Detalhes bibliográficos
Main Authors: Makarewich, Catherine A., Correll, Robert N., Gao, Hui, Zhang, Hongyu, Yang, Baohua, Berretta, Remus M., Rizzo, Victor, Molkentin, Jeffery D., Houser, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324037/
https://ncbi.nlm.nih.gov/pubmed/22302787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.264028
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