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A Caveolae Targeted L-type Ca(2+) Channel Antagonist Inhibits Hypertrophic Signaling Without Reducing Cardiac Contractility
RATIONALE: The source of Ca(2+) to activate pathological cardiac hypertrophy is not clearly defined. Ca(2+) influx through the L-type Ca(2+) channels (LTCCs) determines “contractile” Ca(2+), which is not thought to be the source of “hypertrophic” Ca(2+). However, some LTCCs are housed in caveolin-3...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3324037/ https://ncbi.nlm.nih.gov/pubmed/22302787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.264028 |
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