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PKCα, but not PKCβ or PKCγ, regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approach

Protein kinase Cα (PKCα), PKCβ, and PKCγ comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKCα show enhanced cardiac contractility and reduced susceptibility to heart failure. Recent data also suggest that...

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Main Authors: Liu, Qinghang, Chen, Xiongwen, MacDonnell, Scott M., Kranias, Evangelia G., Lorenz, John N., Leitges, Michael, Houser, Steven R., Molkentin, Jeffery D.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749656/
https://ncbi.nlm.nih.gov/pubmed/19556521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.195313
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