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PKCα, but not PKCβ or PKCγ, regulates contractility and heart failure susceptibility: Implications for ruboxistaurin as a novel therapeutic approach
Protein kinase Cα (PKCα), PKCβ, and PKCγ comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac disease responsiveness. Indeed, mice lacking the gene for PKCα show enhanced cardiac contractility and reduced susceptibility to heart failure. Recent data also suggest that...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749656/ https://ncbi.nlm.nih.gov/pubmed/19556521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.195313 |
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