Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury

RATIONALE: Protein kinase Cα (PKCα) activity and protein level are induced during cardiac disease where it controls myocardial contractility and propensity to heart failure in mice and rats. For example, mice lacking the gene for PKCα have enhanced cardiac contractility and reduced susceptibility to...

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Hlavní autoři: Ladage, Dennis, Tilemann, Lisa, Ishikawa, Kiyotake, Correll, Robert N., Kawase, Yoshiaki, Houser, Steven R., Molkentin, Jeffery D., Hajjar, Roger J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237728/
https://ncbi.nlm.nih.gov/pubmed/21998327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.255687
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