Stimulating Myocardial Regeneration with Periostin Peptide in Large Mammals Improves Function Post-Myocardial Infarction but Increases Myocardial Fibrosis

AIMS: Mammalian myocardium has a finite but limited capacity to regenerate. Experimentally stimulating proliferation of cardiomyocytes with extracellular regeneration factors like periostin enhances cardiac repair in rodents. The aim of this study was to develop a safe method for delivering regenera...

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Autores principales: Ladage, Dennis, Yaniz-Galende, Elisa, Rapti, Kleopatra, Ishikawa, Kiyotake, Tilemann, Lisa, Shapiro, Scott, Takewa, Yoshiaki, Muller-Ehmsen, Jochen, Schwarz, Martin, Garcia, Mario J., Sanz, Javier, Hajjar, Roger J., Kawase, Yoshiaki
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659021/
https://ncbi.nlm.nih.gov/pubmed/23700403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059656
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