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Doxorubicin conjugated with a trastuzumab epitope and an MMP-2 sensitive peptide linker for the treatment of HER2-positive breast cancer

HER2-positive breast cancer correlates with more aggressive tumor growth, a poorer prognosis and reduced overall survival. Currently, trastuzumab (Herceptin), which is an anti-HER2 antibody, is one of the key drugs. There is evidence indicating that conjugation of trastuzumab with chemotherapy drugs...

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Detalhes bibliográficos
Publicado no:Drug Deliv
Main Authors: You, Yiwen, Xu, Zhiyuan, Chen, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058718/
https://ncbi.nlm.nih.gov/pubmed/29405790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2018.1435746
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