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Underestimation of N‐glycoPEGylated factor IX one‐stage clotting activity owing to contact activator‐impaired activation
ESSENTIALS: Nonacog beta pegol (N9‐GP) activity can be underestimated in clot method using diverse reagents. Mimicking clotting phase with representative reagents reveals impaired FIX and N9‐GP activation. Polyethylene glycol conjugation amplifies contact activator‐induced decrease in FIX activation...
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| Publicado no: | Res Pract Thromb Haemost |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6058268/ https://ncbi.nlm.nih.gov/pubmed/30046695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rth2.12046 |
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