Boosting phagocytosis and anti‐inflammatory phenotype in microglia mediates neuroprotection by PPARγ agonist MDG548 in Parkinson's disease models

BACKGROUND AND PURPOSE: Microglial phenotype and phagocytic activity are deregulated in Parkinson's disease (PD). PPARγ agonists are neuroprotective in experimental PD, but their role in regulating microglial phenotype and phagocytosis has been poorly investigated. We addressed it by using the...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Lecca, Daniela, Janda, Elzbieta, Mulas, Giovanna, Diana, Andrea, Martino, Concetta, Angius, Fabrizio, Spolitu, Stefano, Casu, Maria Antonietta, Simbula, Gabriella, Boi, Laura, Batetta, Barbara, Spiga, Saturnino, Carta, Anna R
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057897/
https://ncbi.nlm.nih.gov/pubmed/29570770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14214
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