Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson’s disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates, and that size and topological structural properties are crucial factors fo...

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Pubblicato in:Int J Mol Sci
Autori principali: Boi, Laura, Pisanu, Augusta, Palmas, Maria Francesca, Fusco, Giuliana, Carboni, Ezio, Casu, Maria Antonietta, Satta, Valentina, Scherma, Maria, Janda, Elzbieta, Mocci, Ignazia, Mulas, Giovanna, Ena, Anna, Spiga, Saturnino, Fadda, Paola, De Simone, Alfonso, Carta, Anna R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696693/
https://ncbi.nlm.nih.gov/pubmed/33198335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228535
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