Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson’s disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates, and that size and topological structural properties are crucial factors fo...

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Publicat a:Int J Mol Sci
Autors principals: Boi, Laura, Pisanu, Augusta, Palmas, Maria Francesca, Fusco, Giuliana, Carboni, Ezio, Casu, Maria Antonietta, Satta, Valentina, Scherma, Maria, Janda, Elzbieta, Mocci, Ignazia, Mulas, Giovanna, Ena, Anna, Spiga, Saturnino, Fadda, Paola, De Simone, Alfonso, Carta, Anna R.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696693/
https://ncbi.nlm.nih.gov/pubmed/33198335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228535
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