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Modeling Parkinson’s Disease Neuropathology and Symptoms by Intranigral Inoculation of Preformed Human α-Synuclein Oligomers

The accumulation of aggregated α-synuclein (αSyn) is a hallmark of Parkinson’s disease (PD). Current evidence indicates that small soluble αSyn oligomers (αSynOs) are the most toxic species among the forms of αSyn aggregates, and that size and topological structural properties are crucial factors fo...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Boi, Laura, Pisanu, Augusta, Palmas, Maria Francesca, Fusco, Giuliana, Carboni, Ezio, Casu, Maria Antonietta, Satta, Valentina, Scherma, Maria, Janda, Elzbieta, Mocci, Ignazia, Mulas, Giovanna, Ena, Anna, Spiga, Saturnino, Fadda, Paola, De Simone, Alfonso, Carta, Anna R.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7696693/
https://ncbi.nlm.nih.gov/pubmed/33198335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21228535
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