p8 deficiency leads to elevated pancreatic beta cell mass but does not contribute to insulin resistance in mice fed with high-fat diet

BACKGROUND: p8 was initially described as being overexpressed in acute pancreatitis and encoding a ubiquitous stress protein. Analysis of insulin sensitivity and glucose tolerance in p8-knockout and haplodeficient mice revealed counterintuitive results. Thus, we determined glycemic control of p8 in...

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Publicado en:PLoS One
Autores principales: Hollenbach, Marcus, Klöting, Nora, Sommerer, Ines, Lorenz, Jana, Heindl, Mario, Kern, Matthias, Mössner, Joachim, Blüher, Matthias, Hoffmeister, Albrecht
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057664/
https://ncbi.nlm.nih.gov/pubmed/30040846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201159
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