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No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice
CRISPR-Cas9 technologies have transformed genome-editing of experimental organisms and have immense therapeutic potential. Despite significant advances in our understanding of the CRISPR-Cas9 system, concerns remain over the potential for off-target effects. Recent studies have addressed these conce...
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| Pubblicato in: | PLoS Genet |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6057650/ https://ncbi.nlm.nih.gov/pubmed/29985941 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007503 |
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