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Mechanism for remodelling of the cell cycle checkpoint protein Mad2 by the ATPase TRIP13

The maintenance of genome stability in mitosis is coordinated by the spindle assembly checkpoint (SAC) through its effector the mitotic checkpoint complex (MCC), an APC/C inhibitor 1,2. Unattached kinetochores control MCC assembly by catalysing a change in topology of the β-sheet of Mad2, an MCC sub...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Alfieri, Claudio, Chang, Leifu, Barford, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057611/
https://ncbi.nlm.nih.gov/pubmed/29973720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0281-1
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