Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure

BACKGROUND & AIMS: Acute liver failure is a rapidly progressive deterioration of hepatic function resulting in high mortality and morbidity. Metabolic enzymes can translocate to the nucleus to regulate histone acetylation and gene expression. METHODS: Levels and activities of pyruvate dehydrogen...

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Gepubliceerd in:J Hepatol
Hoofdauteurs: Ferriero, Rosa, Nusco, Edoardo, De Cegli, Rossella, Carissimo, Annamaria, Manco, Giuseppe, Brunetti-Pierri, Nicola
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057136/
https://ncbi.nlm.nih.gov/pubmed/29580866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2018.03.016
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