Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis

DDHD2/KIAA0725p is a mammalian intracellular phospholipase A(1) that exhibits phospholipase and lipase activities. Mutation of the DDHD2 gene causes hereditary spastic paraplegia (SPG54), an inherited neurological disorder characterized by lower limb spasticity and weakness. Although previous studie...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Death Dis
Hlavní autoři: Maruyama, Tomohiro, Baba, Takashi, Maemoto, Yuki, Hara-Miyauchi, Chikako, Hasegawa-Ogawa, Minami, Okano, Hirotaka James, Enda, Yuki, Matsumoto, Kei, Arimitsu, Nagisa, Nakao, Kazuki, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Ohto-Nakanishi, Takayo, Nakanishi, Hiroki, Tokuyama, Takeshi, Yanagi, Shigeru, Tagaya, Mitsuo, Tani, Katsuko
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056544/
https://ncbi.nlm.nih.gov/pubmed/30038238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0815-3
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky