Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis

DDHD2/KIAA0725p is a mammalian intracellular phospholipase A(1) that exhibits phospholipase and lipase activities. Mutation of the DDHD2 gene causes hereditary spastic paraplegia (SPG54), an inherited neurological disorder characterized by lower limb spasticity and weakness. Although previous studie...

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Publicado no:Cell Death Dis
Main Authors: Maruyama, Tomohiro, Baba, Takashi, Maemoto, Yuki, Hara-Miyauchi, Chikako, Hasegawa-Ogawa, Minami, Okano, Hirotaka James, Enda, Yuki, Matsumoto, Kei, Arimitsu, Nagisa, Nakao, Kazuki, Hamamoto, Hiroshi, Sekimizu, Kazuhisa, Ohto-Nakanishi, Takayo, Nakanishi, Hiroki, Tokuyama, Takeshi, Yanagi, Shigeru, Tagaya, Mitsuo, Tani, Katsuko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056544/
https://ncbi.nlm.nih.gov/pubmed/30038238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0815-3
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