Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients

Cathepsin S (CTSS) activity is elevated in Sjögren’s Syndrome (SS) patient tears. Here we tested whether protease inhibition and cystatin C (Cys C) levels are reduced in SS tears, which could lead to enhanced CTSS-driven degradation of tear proteins. CTSS activity against Cys C, LF and sIgA was test...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Edman, Maria C., Janga, Srikanth R., Meng, Zhen, Bechtold, Mercy, Chen, Alexander F., Kim, Chongiin, Naman, Luke, Sarma, Arunava, Teekappanavar, Neha, Kim, Alice Y., Madrigal, Sara, Singh, Simranjit, Ortiz, Elizabeth, Christianakis, Stratos, Arkfeld, Daniel G., Mack, Wendy J., Heur, Martin, Stohl, William, Hamm-Alvarez, Sarah F.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056496/
https://ncbi.nlm.nih.gov/pubmed/30038391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29411-9
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