Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients

Cathepsin S (CTSS) activity is elevated in Sjögren’s Syndrome (SS) patient tears. Here we tested whether protease inhibition and cystatin C (Cys C) levels are reduced in SS tears, which could lead to enhanced CTSS-driven degradation of tear proteins. CTSS activity against Cys C, LF and sIgA was test...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Edman, Maria C., Janga, Srikanth R., Meng, Zhen, Bechtold, Mercy, Chen, Alexander F., Kim, Chongiin, Naman, Luke, Sarma, Arunava, Teekappanavar, Neha, Kim, Alice Y., Madrigal, Sara, Singh, Simranjit, Ortiz, Elizabeth, Christianakis, Stratos, Arkfeld, Daniel G., Mack, Wendy J., Heur, Martin, Stohl, William, Hamm-Alvarez, Sarah F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6056496/
https://ncbi.nlm.nih.gov/pubmed/30038391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29411-9
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