Spiro‐epoxyglycosides as Activity‐Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase

N‐Glycans direct protein function, stability, folding and targeting, and influence immunogenicity. While most glycosidases that process N‐glycans cleave a single sugar residue at a time, enzymes from glycoside hydrolase family 99 are endo‐acting enzymes that cleave within complex N‐glycans. Eukaryot...

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Publicado no:Chemistry
Main Authors: Schröder, Sybrin P., Kallemeijn, Wouter W., Debets, Marjoke F., Hansen, Thomas, Sobala, Lukasz F., Hakki, Zalihe, Williams, Spencer J., Beenakker, Thomas J. M., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Codée, Jeroen D. C., Davies, Gideon J., Overkleeft, Herman S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055899/
https://ncbi.nlm.nih.gov/pubmed/29797675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201801902
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