Total Chemical Synthesis of SUMO and SUMO‐Based Probes for Profiling the Activity of SUMO‐Specific Proteases

SUMO is a post‐translational modifier critical for cell cycle progression and genome stability that plays a role in tumorigenesis, thus rendering SUMO‐specific enzymes potential pharmacological targets. However, the systematic generation of tools for the activity profiling of SUMO‐specific enzymes h...

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Enregistré dans:
Détails bibliographiques
Publié dans:Angew Chem Int Ed Engl
Auteurs principaux: Mulder, Monique P. C., Merkx, Remco, Witting, Katharina F., Hameed, Dharjath S., El Atmioui, Dris, Lelieveld, Lindsey, Liebelt, Frauke, Neefjes, Jacques, Berlin, Ilana, Vertegaal, Alfred C. O., Ovaa, Huib
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2018
Sujets:
Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6055820/
https://ncbi.nlm.nih.gov/pubmed/29771001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201803483
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