SUMO targets the APC/C to regulate transition from metaphase to anaphase

Signal transduction by small ubiquitin-like modifier (SUMO) regulates a myriad of nuclear processes. Here we report on the role of SUMO in mitosis in human cell lines. Knocking down the SUMO conjugation machinery results in a delay in mitosis and defects in mitotic chromosome separation. Searching f...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Eifler, Karolin, Cuijpers, Sabine A. G., Willemstein, Edwin, Raaijmakers, Jonne A., El Atmioui, Dris, Ovaa, Huib, Medema, René H., Vertegaal, Alfred C. O.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856775/
https://ncbi.nlm.nih.gov/pubmed/29549242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03486-4
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