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RCS1, a substrate of APC/C, controls the metaphase to anaphase transition

The anaphase-promoting complex/cyclosome (APC/C) controls the onset of anaphase by targeting securin for destruction. We report here the identification and characterization of a substrate of APC/C, RCS1, as a mitotic regulator that controls the metaphase-to-anaphase transition. We showed that the le...

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Autori principali: Zhao, Wei-meng, Coppinger, Judith A., Seki, Akiko, Cheng, Xiao-li, Yates, John R., Fang, Guowei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2533204/
https://ncbi.nlm.nih.gov/pubmed/18757745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709227105
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