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Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
Designed helical repeats (DHRs) are modular helix–loop–helix–loop protein structures that are tandemly repeated to form a superhelical array. Structures combining tandem DHRs demonstrate a wide range of molecular geometries, many of which are not observed in nature. Understanding cooperativity of DH...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6055163/ https://ncbi.nlm.nih.gov/pubmed/29959204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800283115 |
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