Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors

INTRODUCTION: Radiolabeled, low-molecular-weight prostate-specific membrane antigen (PSMA) inhibitors based on the Glu-ureido pharmacophore show promise for the detection and treatment of castration-resistant prostate cancer; however, high renal retention of activity, related in part to overexpressi...

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I publikationen:Nucl Med Biol
Huvudupphovsmän: Vaidyanathan, Ganesan, Kang, Choong Mo, McDougald, Darryl, Minn, Il, Brummet, Mary, Pomper, Martin G., Zalutsky, Michael R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054815/
https://ncbi.nlm.nih.gov/pubmed/29803076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2018.05.002
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