The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas

Loss-of-function of alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein leads to a phenotype called alternative lengthening of telomeres (ALT) in some tumors. High-grade astrocytomas comprise a heterogeneous group of central nervous system tumors. We examined a large cohort of adul...

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Udgivet i:Mod Pathol
Main Authors: Abedalthagafi, Malak, Phillips, Joanna J, Kim, Grace E, Mueller, Sabine, Haas-Kogen, Daphne A, Marshall, Roxanne E, Croul, Sidney E, Santi, Mariarita R, Cheng, Jing, Zhou, Shengmei, Sullivan, Lisa M, Martinez-Lage, Maria, Judkins, Alexander R, Perry, Arie
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054791/
https://ncbi.nlm.nih.gov/pubmed/23765250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/modpathol.2013.90
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