The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomerase expression, the main pathway in most cancer types, or to activation of a mechanism call...

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Publicat a:Acta Neuropathol Commun
Autors principals: Grandin, Nathalie, Pereira, Bruno, Cohen, Camille, Billard, Pauline, Dehais, Caroline, Carpentier, Catherine, Idbaih, Ahmed, Bielle, Franck, Ducray, François, Figarella-Branger, Dominique, Delattre, Jean-Yves, Sanson, Marc, Lomonte, Patrick, Poncet, Delphine, Verrelle, Pierre, Charbonneau, Michel
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842523/
https://ncbi.nlm.nih.gov/pubmed/31706351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0833-0
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