The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomerase expression, the main pathway in most cancer types, or to activation of a mechanism call...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Grandin, Nathalie, Pereira, Bruno, Cohen, Camille, Billard, Pauline, Dehais, Caroline, Carpentier, Catherine, Idbaih, Ahmed, Bielle, Franck, Ducray, François, Figarella-Branger, Dominique, Delattre, Jean-Yves, Sanson, Marc, Lomonte, Patrick, Poncet, Delphine, Verrelle, Pierre, Charbonneau, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842523/
https://ncbi.nlm.nih.gov/pubmed/31706351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0833-0
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