The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomerase expression, the main pathway in most cancer types, or to activation of a mechanism call...

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發表在:Acta Neuropathol Commun
Main Authors: Grandin, Nathalie, Pereira, Bruno, Cohen, Camille, Billard, Pauline, Dehais, Caroline, Carpentier, Catherine, Idbaih, Ahmed, Bielle, Franck, Ducray, François, Figarella-Branger, Dominique, Delattre, Jean-Yves, Sanson, Marc, Lomonte, Patrick, Poncet, Delphine, Verrelle, Pierre, Charbonneau, Michel
格式: Artigo
語言:Inglês
出版: BioMed Central 2019
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6842523/
https://ncbi.nlm.nih.gov/pubmed/31706351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0833-0
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