Late-stage Deuteration of (13)C-enriched Substrates for T(1) Prolongation in Hyperpolarized (13)C MRI

A robust and selective late-stage deuteration methodology was applied to (13)C-enriched amino and alpha hydroxy acids to increase spin-lattice relaxation constant T(1) for hyperpolarized (13)C magnetic resonance imaging. For the five substrates with (13)C-labeling on the C1-position ([1-(13)C]alanin...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Taglang, Céline, Korenchan, David E., von Morze, Cornelius, Yu, Justin, Najac, Chloé, Wang, Sinan, Blecha, Joseph E., Subramaniam, Sukumar, Bok, Robert, VanBrocklin, Henry F., Vigneron, Daniel B., Ronen, Sabrina M., Sriram, Renuka, Kurhanewicz, John, Wilson, David M., Flavell, Robert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054790/
https://ncbi.nlm.nih.gov/pubmed/29726563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cc02246a
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