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Dicarboxylic Acids as pH Sensors for Hyperpolarized (13)C Magnetic Resonance Spectroscopic Imaging
Imaging tumoral pH may help characterize aggressiveness, metastasis, and therapeutic response. We report the development of hyperpolarized [2–(13)C,D(10)]diethylmalonic acid, which exhibits a large pH-dependent (13)C chemical shift over the physiologic range. We demonstrate that co-polarization with...
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| Publicado no: | Analyst |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5462110/ https://ncbi.nlm.nih.gov/pubmed/28322385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7an00076f |
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