Variability of Directly Measured First-Pass Hepatic Insulin Extraction and Its Association With Insulin Sensitivity and Plasma Insulin

Although the β-cells secrete insulin, the liver, with its first-pass insulin extraction (FPE), regulates the amount of insulin allowed into circulation for action on target tissues. The metabolic clearance rate of insulin, of which FPE is the dominant component, is a major determinant of insulin sen...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Asare-Bediako, Isaac, Paszkiewicz, Rebecca L., Kim, Stella P., Woolcott, Orison O., Kolka, Cathryn M., Burch, Miguel A., Kabir, Morvarid, Bergman, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054441/
https://ncbi.nlm.nih.gov/pubmed/29752425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-1520
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