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Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation
Integrin-based adhesions play critical roles in cell migration. Talin activates integrins and flexibly connects integrins to the actomyosin cytoskeleton, thereby serving as a ‘molecular clutch’ that transmits forces to the extracellular matrix to drive cell migration. Here we identify the evolutiona...
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| Publicat a: | Nat Cell Biol |
|---|---|
| Autors principals: | , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6053543/ https://ncbi.nlm.nih.gov/pubmed/27548916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3402 |
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