CTC1-STN1 terminates telomerase while STN1-TEN1 enables C-strand synthesis during telomere replication in colon cancer cells

Telomerase elongates the telomeric G-strand to prevent telomere shortening through conventional DNA replication. However, synthesis of the complementary C-strand by DNA polymerase α is also required to maintain telomere length. Polymerase α cannot perform this role without the ssDNA binding complex...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Feng, Xuyang, Hsu, Shih-Jui, Bhattacharjee, Anukana, Wang, Yongyao, Diao, Jiajie, Price, Carolyn M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053418/
https://ncbi.nlm.nih.gov/pubmed/30026550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05154-z
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