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CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance
To prevent progressive telomere shortening as a result of conventional DNA replication, new telomeric DNA must be added onto the chromosome end. The de novo DNA synthesis involves elongation of the G-rich strand of the telomere by telomerase. In human cells, the CST complex (CTC1-STN1-TEN1) also fun...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5416890/ https://ncbi.nlm.nih.gov/pubmed/28334750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx125 |
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