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The human CTC1/STN1/TEN1 complex regulates telomere maintenance in ALT cancer cells

Maintaining functional telomeres is important for long-term proliferation of cells. About 15% of cancer cells are telomerase-negative and activate the alternative-lengthening of telomeres (ALT) pathway to maintain their telomeres. Recent studies have shown that the human CTC1/STN1/TEN1 complex (CST)...

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Detalhes bibliográficos
Publicado no:Exp Cell Res
Main Authors: Huang, Chenhui, Jia, Pingping, Chastain, Megan, Shiva, Olga, Chai, Weihang
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551977/
https://ncbi.nlm.nih.gov/pubmed/28366536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2017.03.058
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