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Enzymatic one-step ring contraction for quinolone biosynthesis

The 6,6-quinolone scaffolds on which viridicatin-type fungal alkaloids are built are frequently found in metabolites that display useful biological activities. Here we report in vitro and computational analyses leading to the discovery of a hemocyanin-like protein AsqI from the Aspergillus nidulans...

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Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Kishimoto, Shinji, Hara, Kodai, Hashimoto, Hiroshi, Hirayama, Yuichiro, Champagne, Pier Alexandre, Houk, Kendall N., Tang, Yi, Watanabe, Kenji
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053404/
https://ncbi.nlm.nih.gov/pubmed/30026518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05221-5
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