CYP2D6 protein level is the major contributor to inter-individual variability in CYP2D6-mediated drug metabolism in healthy human liver tissue

CYP2D6 genetic polymorphisms are considered a major contributor to the large inter-individual variability in CYP2D6-mediated drug metabolism, but fail to explain significant portion of the variability. The aim of this study was to assess the ability of CYP2D6 activity score (AS) estimated from CYP2D...

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Bibliographic Details
Published in:Clin Pharmacol Ther
Main Authors: Ning, Miaoran, Duarte, Julio D., Rubin, Leah H., Jeong, Hyunyoung
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053340/
https://ncbi.nlm.nih.gov/pubmed/29349771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1032
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