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Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice
Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme, but the factors governing transcriptional regulation of its expression remain poorly understood. Based on previous reports of small heterodimer partner (SHP) playing an important role as a transcriptional repressor of CYP2D6 expressio...
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| Gepubliceerd in: | Drug Metab Dispos |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5363697/ https://ncbi.nlm.nih.gov/pubmed/28153841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074013 |
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