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Cholic Acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice

Cytochrome P450 2D6 (CYP2D6) is a major drug-metabolizing enzyme, but the factors governing transcriptional regulation of its expression remain poorly understood. Based on previous reports of small heterodimer partner (SHP) playing an important role as a transcriptional repressor of CYP2D6 expressio...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Metab Dispos
Hauptverfasser: Pan, Xian, Kent, Rebecca, Won, Kyoung-Jae, Jeong, Hyunyoung
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5363697/
https://ncbi.nlm.nih.gov/pubmed/28153841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074013
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