Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells

BACKGROUND: Impairment in mitochondrial biogenesis and function plays a key role in depression and anxiety, both of which being associated with changes in fatty acid and phospholipid metabolism. The antidepressant effects of (R,S)-ketamine have been linked to its conversion into (2S,6S;2R,6R)-hydrox...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Faccio, Andréa T., Ruperez, Francisco J., Singh, Nagendra S., Angulo, Santiago, Tavares, Marina F. M., Bernier, Michel, Barbas, Coral, Wainer, Irving W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053273/
https://ncbi.nlm.nih.gov/pubmed/29526507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.03.008
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