Discovery and validation of autosomal dominant Alzheimer’s disease mutations

BACKGROUND: Alzheimer’s disease (AD) is a neurodegenerative disease that is clinically characterized by progressive cognitive decline. Mutations in amyloid-β precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2) are the pathogenic cause of autosomal dominant AD (ADAD). However, pol...

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Dades bibliogràfiques
Publicat a:Alzheimers Res Ther
Autors principals: Hsu, Simon, Gordon, Brian A., Hornbeck, Russ, Norton, Joanne B., Levitch, Denise, Louden, Adia, Ziegemeier, Ellen, Laforce, Robert, Chhatwal, Jasmeer, Day, Gregory S., McDade, Eric, Morris, John C., Fagan, Anne M., Benzinger, Tammie L. S., Goate, Alison M., Cruchaga, Carlos, Bateman, Randall J., Karch, Celeste M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052673/
https://ncbi.nlm.nih.gov/pubmed/30021643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0392-9
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