VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and sometimes causes severe or fatal neurological complications. The amino acid at VP1-145 determines the virological characteristics of EV71. Viruses with glutamic acid (E) at VP1-145 (VP1-145E) are virulent in neonatal mic...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Fujii, Ken, Sudaka, Yui, Takashino, Ayako, Kobayashi, Kyousuke, Kataoka, Chikako, Suzuki, Tadaki, Iwata-Yoshikawa, Naoko, Kotani, Osamu, Ami, Yasushi, Shimizu, Hiroyuki, Nagata, Noriyo, Mizuta, Katsumi, Matsuzaki, Yoko, Koike, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052295/
https://ncbi.nlm.nih.gov/pubmed/29848582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00682-18
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