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The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability
In the yeast Saccharomyces cerevisiae, genomic instability in rDNA repeat sequences is an underlying cause of cell aging and is suppressed by the chromatin-silencing factor Sir2. In humans, rDNA instability is observed in cancers and premature aging syndromes, but its underlying mechanisms and funct...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052228/ https://ncbi.nlm.nih.gov/pubmed/29728458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC118.003325 |
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