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The epigenetic regulator SIRT7 guards against mammalian cellular senescence induced by ribosomal DNA instability
In the yeast Saccharomyces cerevisiae, genomic instability in rDNA repeat sequences is an underlying cause of cell aging and is suppressed by the chromatin-silencing factor Sir2. In humans, rDNA instability is observed in cancers and premature aging syndromes, but its underlying mechanisms and funct...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052228/ https://ncbi.nlm.nih.gov/pubmed/29728458 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.AC118.003325 |
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