Impact of tobacco-specific nitrosamine–derived DNA adducts on the efficiency and fidelity of DNA replication in human cells

The tobacco-derived nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and N′-nitrosonornicotine (NNN) are known human carcinogens. Following metabolic activation, NNK and NNN can induce a number of DNA lesions, including several 4-(3-pyridyl)-4-oxobut-1-yl (POB) adducts. However, it...

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Vydáno v:J Biol Chem
Hlavní autoři: Du, Hua, Leng, Jiapeng, Wang, Pengcheng, Li, Lin, Wang, Yinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
DNA and Chromosomes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052226/
https://ncbi.nlm.nih.gov/pubmed/29789427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003477
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