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Decline in arylsulfatase B expression increases EGFR expression by inhibiting the protein-tyrosine phosphatase SHP2 and activating JNK in prostate cells

Epidermal growth factor receptor (EGFR) has a crucial role in cell differentiation and proliferation and cancer, and its expression appears to be up-regulated when arylsulfatase B (ARSB or GalNAc-4-sulfatase) is reduced. ARSB removes 4-sulfate groups from the nonreducing end of dermatan sulfate and...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Bhattacharyya, Sumit, Feferman, Leo, Han, Xiaorui, Ouyang, Yilan, Zhang, Fuming, Linhardt, Robert J., Tobacman, Joanne K.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052222/
https://ncbi.nlm.nih.gov/pubmed/29794138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001244
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