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Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
Inflammation is a major driver of tumor progression and metastasis, although the mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown. Interleukin-6 (IL-6) is a potent proinflammatory cytokine that is elevated in individuals with pancreatic cancer (PDAC), is required f...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6052214/ https://ncbi.nlm.nih.gov/pubmed/29853638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003276 |
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