Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic–aromatic interactions

Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within amino acids and peptide bonds. Of particular interest are aromatic side chains whose directional π-systems commonly stabilize protein interiors...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Rege, Nischay K., Wickramasinghe, Nalinda P., Tustan, Alisar N., Phillips, Nelson F. B., Yee, Vivien C., Ismail-Beigi, Faramarz, Weiss, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052209/
https://ncbi.nlm.nih.gov/pubmed/29880646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003650
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