Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic–aromatic interactions

Key contributions to protein structure and stability are provided by weakly polar interactions, which arise from asymmetric electronic distributions within amino acids and peptide bonds. Of particular interest are aromatic side chains whose directional π-systems commonly stabilize protein interiors...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Rege, Nischay K., Wickramasinghe, Nalinda P., Tustan, Alisar N., Phillips, Nelson F. B., Yee, Vivien C., Ismail-Beigi, Faramarz, Weiss, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052209/
https://ncbi.nlm.nih.gov/pubmed/29880646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003650
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