Protein kinase Cα drives fibroblast activation and kidney fibrosis by stimulating autophagic flux

Kidney fibrosis is a histological hallmark of chronic kidney disease and arises in large part through extracellular matrix deposition by activated fibroblasts. The signaling protein complex mTOR complex 2 (mTORC2) plays a critical role in fibroblast activation and kidney fibrosis. Protein kinase Cα...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Xue, Xian, Ren, Jiafa, Sun, Xiaoli, Gui, Yuan, Feng, Ye, Shu, Bingyan, Wei, Wei, Lu, Qingmiao, Liang, Yan, He, Weichun, Yang, Junwei, Dai, Chunsun
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2018
Sujets:
Signal Transduction
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052200/
https://ncbi.nlm.nih.gov/pubmed/29794026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002191
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