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Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase

The xenotopic expression of the alternative oxidase AOX from the tunicate Ciona intestinalis in diverse models of human disease partially alleviates the phenotypic effects of mitochondrial respiratory chain defects. AOX is a non-proton pumping, mitochondrial inner membrane-bound, single-subunit enzy...

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Publicado en:Sci Rep
Main Authors: Rodrigues, Ana Paula C., Camargo, André F., Andjelković, Ana, Jacobs, Howard T., Oliveira, Marcos T.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052043/
https://ncbi.nlm.nih.gov/pubmed/30022066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-29150-x
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