Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies

The mitochondrial alternative oxidase, AOX, carries out the non proton-motive re-oxidation of ubiquinol by oxygen in lower eukaryotes, plants and some animals. Here we created a modified version of AOX from Ciona instestinalis, carrying mutations at conserved residues predicted to be required for ch...

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Publicado en:Sci Rep
Autores principales: Andjelković, Ana, Oliveira, Marcos T., Cannino, Giuseppe, Yalgin, Cagri, Dhandapani, Praveen K., Dufour, Eric, Rustin, Pierre, Szibor, Marten, Jacobs, Howard T.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4682143/
https://ncbi.nlm.nih.gov/pubmed/26672986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18295
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