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The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-induced Inflammation
Potassium (K(+)) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K(+) channel (K(2P)) TWIK2 as the K(+) efflux channel triggerin...
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| Izdano u: | Immunity |
|---|---|
| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6051907/ https://ncbi.nlm.nih.gov/pubmed/29958799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2018.04.032 |
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